BEED: Bladder Cancer Epidemiology and Early Detection in Africa study
The BEED study aims to examine the role of infections in bladder cancer in Africa, the lifestyle and environmental risk factors for bladder cancer in Africa, and the potential use of mutations in the promoter of the TERT gene (TERTpm) as a biomarker for the early diagnosis of bladder tumours in Africa and for the triage of symptomatic patients.
HEADSpAcE
The Translational Studies of Head and Neck Cancer in South America and Europe (HEADSpAcE) project is a unique study that will investigate multiple reasons for the poor prognosis of head and neck cancers, including individual and structural reasons for late diagnosis. A major reason for the high mortality rate of head and neck cancers is the late stage at diagnosis for many patients. The impact of HEADSpAcE will be to elucidate reasons for late diagnosis and reduce the proportion of head and neck cancers that are diagnosed at a very late stage. Guidelines will be developed for implementation in clinical care. HEADSpAcE is funded by the European Commission and brings together a consortium of 18 partner institutions from four continents.
Integrative Analysis of Lung Cancer Etiology and Risk
This project focuses on evaluating a comprehensive panel of biomarkers of lung cancer risk that have been implicated in previous studies and the extent to which they may inform risk prediction. This is achieved by bringing together data from ongoing large-scale biomarker studies and conducting a comprehensive analysis of promising risk biomarkers within the Lung Cancer Cohort Consortium (LC3).
Mutographs project
The Mutographs research project aims to advance the understanding of the causes of cancer through studies of mutational signatures by (i) elucidating the causes of major global geographical and temporal differences in cancer incidence through the study of mutational signatures, (ii) identifying and characterizing the biological processes underlying mutational signatures, and (iii) surveying and monitoring mutagenic exposures in normal cells in humans through mutational signature analysis.
Rare Cancers Genomics initiative
The Rare Cancers Genomics initiative is an international multidisciplinary open science effort to shed light on the molecular characteristics of rare cancers, to understand their etiology and carcinogenesis processes, and to ultimately improve their clinical management and consequently their prognosis. The current research has two axes: one on malignant pleural mesothelioma (the MESOMICS and MESOMICS2 projects), and one on neuroendocrine neoplasms (the lungNENomics and panNENomics projects).
The Lung Cancer Cohort Consortium (LC3)
The LC3 was formed to carry out collaborative research on lung cancer risk and etiology as a signature project of the United States National Cancer Institute (NCI) Cohort Consortium. The centralized LC3 database includes risk factor and clinical information from more than 3 million longitudinally followed research participants, including 70 000 incident lung cancer cases.
VOYAGER
The VOYAGER project brings together a consortium of five cohort studies, including three studies in North America and two studies in the United Kingdom and Europe, to learn more about how inherited genetic factors affect risk and outcomes of oral cavity cancer and human papillomavirus (HPV) infection-related oropharyngeal cancers.
