Epigenomics and Mechanisms Branch (EGM)

Publications

1. Ghantous A, Nusslé SG, Nassar FJ, Spitz N, Novoloaca A, Krali O, et al. (2024). Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth. Mol Cancer. 23(1):238. https://doi.org/10.1186/s12943-024-02118-4 PMID:39443995
2. Maroui MA, Odongo GA, Mundo L, Manara F, Mure F, Fusil F, et al. (2024). Aflatoxin B1 and Epstein-Barr virus-induced CCL22 expression stimulates B cell infection. Proc Natl Acad Sci U S A. 121(16):e2314426121. https://doi.org/10.1073/pnas.2314426121 PMID:38574017
3. Vicente A, Novoloaca A, Cahais V, Awada Z, Cuenin C, Spitz N, et al. (2022). Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure. Nat Commun. 13(1):4115. https://doi.org/10.1038/s41467-022-31488-w PMID:35840550
4. Das S, Thakur S, Korenjak M, Sidorenko VS, Chung FF, Zavadil J (2022). Aristolochic acid-associated cancers: a public health risk in need of global action. Nat Rev Cancer. 22(10):576–591. https://doi.org/10.1038/s41568-022-00494-x PMID:35854147
5. Talukdar FR, Soares Lima SC, Khoueiry R, Laskar RS, Cuenin C, Sorroche BP, et al. (2021). Genome-wide DNA methylation profiling of esophageal squamous cell carcinoma from global high-incidence regions identifies crucial genes and potential cancer markers. Cancer Res. 81(10):2612–2624. https://doi.org/10.1158/0008-5472.Can-20-3445 https://PMID:33741694
6. Chung FF, Maldonado SG, Nemc A, Bouaoun L, Cahais V, Cuenin C, et al. (2023). Buffy coat signatures of breast cancer risk in a prospective cohort study. Clin Epigenetics. 15(1):102. https://doi.org/10.1186/s13148-023-01509-6 PMID:37309009
7. Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, et al. (2019). Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. Genome Res. 29(4):521–531. https://doi.org/10.1101/gr.242453.118 PMID:30846532
8. Gheit T, Muwonge R, Lucas E, Galati L, Anantharaman D, McKay-Chopin S, et al. (2023). Impact of HPV vaccination on HPV-related oral infections. Oral Oncol. 136:106244. https://doi.org/10.1016/j.oraloncology.2022.106244 PMID:36402055
9. Sklias A, Halaburkova A, Vanzan L, Jimenez NF, Cuenin C, Bouaoun L, et al. (2021). Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation. Nucleic Acids Res. 49(17):9738–9754. https://doi.org/10.1093/nar/gkab697 PMID:34403459
10. Halaburkova A, Cahais V, Novoloaca A, Araujo M, Khoueiry R, Ghantous A, et al. (2020). Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes. Genome Res. 30(10):1517–1532. https://doi.org/10.1101/gr.268292.120 PMID:32963031
11. Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, et al. (2020). Publisher Correction: Personalized early detection and prevention of breast cancer: ENVISION consensus statement. Nat Rev Clin Oncol. 17(11):716. https://doi.org/10.1038/s41571-020-0412-0 PMID:32601456
12. Karabegović I, Portilla-Fernandez E, Li Y, Ma J, Maas SCE, Sun D, et al. (2021). Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Nat Commun. 12(1):2830. https://doi.org/10.1038/s41467-021-22752-6 PMID:33990564
13. Chung FF, Herceg Z (2020). The promises and challenges of toxico-epigenomics: environmental chemicals and their impacts on the epigenome. Environ Health Perspect. 128(1):15001. https://doi.org/10.1289/ehp6104 PMID:31950866
14. Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, et al. (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nat Commun. 10(1):1893. https://doi.org/10.1038/s41467-019-09671-3 PMID:31015461
15. Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, et al. (2017). Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. Genome Res. 27(9):1475–1486. https://doi.org/10.1101/gr.220038.116 PMID:28739859
16. Woo HD, Fernandez-Jimenez N, Ghantous A, Degli Esposti D, Cuenin C, Cahais V, et al. (2018). Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori– and cancer-associated DNA methylome changes. Int J Cancer. 143(3):597–609. https://doi.org/10.1002/ijc.31381 PMID:29574700
17. Huskova H, Ardin M, Weninger A, Vargova K, Barrin S, Villar S, et al. (2017). Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. Oncogene. 36(43):6041–6048. https://doi.org/10.1038/onc.2017.215 PMID:28692054
18. Degli Esposti D, Sklias A, Lima SC, Beghelli-de la Forest Divonne S, Cahais V, Fernandez-Jimenez N, et al. (2017). Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas. Genome Med. 9(1):33. https://doi.org/10.1186/s13073-017-0419-z PMID:28381277
19. Karanović S, Ardin M, Tang Z, Tomić K, Villar S, Renard C, et al. (2022). Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure. Int J Cancer. 150(2):374–386. https://doi.org/10.1002/ijc.33827 PMID:34569060
20. Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, et al. (2016). DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis. Am J Hum Genet. 98(4):680–696. https://doi.org/10.1016/j.ajhg.2016.02.019 PMID:27040690