Epigenomics and Mechanisms Branch (EGM)

Publications

1. Vicente A, Novoloaca A, Cahais V, Awada Z, Cuenin C, Spitz N, et al. (2022). Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure. Nat Commun. 13(1): 4115. https://doi.org/10.1038/s41467-022-31488-w PMID:35840550
2. Das S, Thakur S, Korenjak M, Sidorenko VS, Chung FF, Zavadil J (2022). Aristolochic acid-associated cancers: a public health risk in need of global action. Nat Rev Cancer. 22(10): 576-591. https://doi.org/10.1038/s41568-022-00494-x PMID:35854147
3. Talukdar FR, Soares Lima SC, Khoueiry R, Laskar RS, Cuenin C, Sorroche BP, et al. (2021). Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers. Cancer Res. 81(10): 2612-2624. https://doi.org/10.1158/0008-5472.Can-20-3445 https://PMID:33741694
4. Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, et al. (2019). Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. Genome Res. 29(4): 521-531. https://doi.org/10.1101/gr.242453.118 PMID:30846532
5. Gheit T, Muwonge R, Lucas E, Galati L, Anantharaman D, McKay-Chopin S, et al. (2023). Impact of HPV vaccination on HPV-related oral infections. Oral Oncol. 136: 106244. https://doi.org/10.1016/j.oraloncology.2022.106244 PMID:36402055
6. Nwanaji-Enwerem JC, Chung FF, Van der Laan L, Novoloaca A, Cuenin C, Johansson H, et al. (2021). An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors. Clin Epigenetics. 13(1): 224. https://doi.org/10.1186/s13148-021-01218-y PMID:34920739
7. Sklias A, Halaburkova A, Vanzan L, Jimenez NF, Cuenin C, Bouaoun L, et al. (2021). Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation. Nucleic Acids Res. 49(17): 9738-9754. https://doi.org/10.1093/nar/gkab697 PMID:34403459
8. Halaburkova A, Cahais V, Novoloaca A, Araujo M, Khoueiry R, Ghantous A, et al. (2020). Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes. Genome Res. 30(10): 1517-1532. https://doi.org/10.1101/gr.268292.120 PMID:32963031
9. Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, et al. (2020). Publisher Correction: Personalized early detection and prevention of breast cancer: ENVISION consensus statement. Nat Rev Clin Oncol. 17(11): 716. https://doi.org/10.1038/s41571-020-0412-0 PMID:32601456
10. Karabegović I, Portilla-Fernandez E, Li Y, Ma J, Maas SCE, Sun D, et al. (2021). Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Nat Commun. 12(1): 2830. https://doi.org/10.1038/s41467-021-22752-6 PMID:33990564
11. Chung FF, Herceg Z (2020). The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome. Environ Health Perspect. 128(1): 15001. https://doi.org/10.1289/ehp6104 PMID:31950866
12. Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, et al. (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nat Commun. 10(1): 1893. https://doi.org/10.1038/s41467-019-09671-3 PMID:31015461
13. Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, et al. (2017). Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. Genome Res. 27(9): 1475-1486. https://doi.org/10.1101/gr.220038.116 PMID:28739859
14. Woo HD, Fernandez-Jimenez N, Ghantous A, Degli Esposti D, Cuenin C, Cahais V, et al. (2018). Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes. Int J Cancer. 143(3): 597-609. https://doi.org/10.1002/ijc.31381 PMID:29574700
15. Huskova H, Ardin M, Weninger A, Vargova K, Barrin S, Villar S, et al. (2017). Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. Oncogene. 36(43): 6041-6048. https://doi.org/10.1038/onc.2017.215 PMID:28692054
16. Degli Esposti D, Sklias A, Lima SC, Beghelli-de la Forest Divonne S, Cahais V, Fernandez-Jimenez N, et al. (2017). Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas. Genome Med. 9(1): 33. https://doi.org/10.1186/s13073-017-0419-z PMID:28381277
17. Thakur S, Cahais V, Turkova T, Zikmund T, Renard C, Stopka T, et al. (2022). Chromatin Remodeler Smarca5 Is Required for Cancer-Related Processes of Primary Cell Fitness and Immortalization. Cells. 11(5). https://doi.org/10.3390/cells11050808 PMID:35269430
18. Karanović S, Ardin M, Tang Z, Tomić K, Villar S, Renard C, et al. (2022). Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure. Int J Cancer. 150(2): 374-386. https://doi.org/10.1002/ijc.33827 PMID:34569060
19. Barupal DK, Schubauer-Berigan MK, Korenjak M, Zavadil J, Guyton KZ (2021). Prioritizing cancer hazard assessments for IARC Monographs using an integrated approach of database fusion and text mining. Environ Int. 156: 106624. https://doi.org/10.1016/j.envint.2021.106624 PMID:33984576
20. Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, et al. (2016). DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 98(4): 680-696. https://doi.org/10.1016/j.ajhg.2016.02.019 PMID:27040690